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46. Shu, X., Asghar, S., Yang, F., Li, S. T.*, Wu, H.*, & Yang, B.* (2022). Uncover New Reactivity of Genetically Encoded Alkyl Bromide Non-Canonical Amino Acids. Frontiers in chemistry, 10, 815991.

45. Belsare, K. D., Wu, H., Mondal, D., Bond, A., Castillo, E., Jin, J., Jo, H., Roush, A. E., Pilla, K. B., Sali, A., Condello, C., & DeGrado, W. F. (2022). Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. PNAS, 119(5), e2114486119.

44. Duan, P., Chen, K. J., Wijegunawardena, G., Dregni, A. J., Wang, H. K., Wu, H.*, & Hong, M.* (2022). Binding Sites of a Positron Emission Tomography Imaging Agent in Alzheimer's β-Amyloid Fibrils Studied Using 19F Solid-State NMRJ. Am. Chem. Soc., 144(3), 1416–1430.

43. Dregni, A.J.; Wang, H. K.; Wu, H.; Duan, P. ; DeGrado, W.F.; Hong, M. Inclusion of the C-Terminal Domain in the Tau Amyloid Fibril Core Revealed by Solid-State NMR SpectroscopyJ. Am. Chem. Soc., 2021, 143, 7839-7851.

42. Dregni, A.J.;# Mandala, V.S.;# Wu, H.;# Elkins, M.R.; Wang, H.; Hung, I.; DeGrado, W.F.; Hong, M. In Vitro 0N4R Tau Fibrils Contain a Monomorphic β-sheet Core Enclosed by Dynamically Heterogeneous Fuzzy Coat Segments. PNAS 2019, 116 (33), 16357-16366.

41. Wu, H.; Saltzberg, D.J; Kratochvil, H.; Jo, H.; Sali, A.; DeGrado, W.F. Glutamine side chain 13C=18O as a non-perturbative IR probe of amyloid fibril hydration and assembly. J. Am. Chem. Soc. 2019, 141 (18), 7320-7326.

40. Zhang, Q.; Schepis, A.; Huang, H.; Yang, J.; Ma, W.; Torra, J.; Zhang, S.; Yang, L.; Wu, H.; Nonell, S; Dong, Z.; Kornberg, T.B.; Coughlin, S.R.; Shu, X. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals. J. Am. Chem. Soc. 2019, 141 (11), 4526–4530.

39. Acharyya, A.; # Ge, Y.; # Wu, H.; # DeGrado, W.F.; Voelz, V.A. Gai, F. Exposing the nucleation site in α-helix folding: a joint experimental and simulation study. J. Phys. Chem. B. 2019, 123, 1797−1807.

38. Yang, B.;# Wu, H.;# Schnier, P.D.;# Liu, Y.;# Liu, J.; Wang, N.; DeGrado, W.F.; Wang, L. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. PNAS, 2018, 115(44):11162-11167.

37. Liu, J.; Cheng, R.; Wu, H.; Li, S.; Wang, P.G.; DeGrado, W.F.; Rozovsky, S.; Wang, L. Building and breaking bonds via a compact s-propargyl-cysteine to chemically control enzymes and modify proteins. Angew. Chem. Int. Ed., 2018, 130, 12884 –12888.

36. Wu, H.; Acharyya, A.; Wu, Y.; Liu, L.; Jo, H.; Gai, F.; DeGrado, W.F. Design of a short thermally stable α-helix embedded in a macrocycle. ChemBioChem 19 (9), 902-906. (selected as the cover picture)

35. Dang, B.;# Wu, H.;# Mulligan, V.K.;# Mravic, M.; Wu, Y.; Lemmin, T.; Ford, A.; Silva, D.; Baker, D.; DeGrado, W.F.  De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. PNAS, 2017, 114 (41), 10852-10857.

34. Stöhr, J.;# Wu, H.;# Nick, M.;# Wu, Y.; Bhate, M.; Condello, C.; Johnson, N.; Rodgers, J.; Lemmin, T.; Achyraya, S.; Becker, J.; Robinson, H.; Kelly, M.; Gai, F.; Stubbs, G.; Prusiner, S.B.; DeGrado, W.F. A 31-residue peptide induces aggregation of tau’s microtubule-binding region in cells. Nat. Chem. 2017, 9(9):874-881. 

33. Lee, M.; Wang, T.; Makhlynets, O.V.; Wu, Y.; Polizzi, N.; Wu, H.; Gosavi, P.M.; Korendovych, I.V.; DeGrado, W.F.; Hong, M. Zinc-binding structure of a catalytic amyloid from solid-state NMR spectroscopy. PNAS, 2017 114 (24), 6191-6196.

32. Gao, W.Y.; Wu, H.; Leng, K.; Sun, Y.; Ma, S. Inserting CO2 into aryl C-H bonds of metal-organic frameworks: CO2 utilization for direct heterogeneous C-H activation. Angew. Chem. Int. Ed., 2016, 55, 5472-5476.

31. Wu, H.; Jiang, J.; Xu, H.; Li, Q.; Cai. J. RGD mimetic γ-AApeptides and methods of use us 20140004039 a1: a patent evaluation. Expert Opin. Ther. Pat., 2016, 26, 131-137.

30. Wu, H.; Qiao, Q; Teng, P.; Hu, Y.; Antoniadis, D.; Zuo, X.; Cai, J. A new class of heterogeneous helical peptidomimetics. Org. Lett., 2015, 17, 3524-3527.

29. Wu, H.; She, F.; Gao, W.; Prince, A.; Li, Y.; Wei, L.; Mercer, A.; Wojtas, L.; Ma, S.; Cai, J. The synthesis of head-to-tail cyclic sulfono-γ-AApeptides. Org. Biomol. Chem., 2015, 13 (3), 672-676.

28. Wu, H.; Qiao, Q.; Hu, Y.; Teng, P.; Gao, W.; Zuo, X.; Wojtas, L.; Larsen, R.; Ma, S.; Cai, J. Sulfono-γ-AApeptides as a new class of unnatural helical foldamer. Chem. Eur. J., 2015, 21, 2501-2507.

27. Li, Y.; Wu, H.; Teng, P.; Bai, G.; Lin, X.; Zuo, X.; Cao, C.; Cai, J. Helical antimicrobial sulfono-γ-AApeptides. J. Med. Chem., 2015, 58, 4802-4811.

26. Teng, P.; Wu, H.; Cai, J. Antimicrobial Gamma-AApeptides (WO2013112548): a patent evaluation. Expert Opin. Ther. Pat.. 2015, 25(1), 111-118.

25. Wu, H.; Teng, P.; Cai, J. Rapid access to multiple classes of peptidomimetics from common γ-AApeptide building blocks. Eur. J. Org., 2014, 8, 1760-1765.

24. Wu, H.; Li, Y.; Bai, G.; Niu, Y.; Qiao, Q.; Tipton, J.; Cao, C.; Cai, J. γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation. Chem. Commun., 2014, 50(40), 5206 - 5208.

23. Hu, Y.; Cheng, N.; Wu, H.; Kang, S.; Ye, R. D.; Cai, J. Design, synthesis and characterization of fMLF-mimicking AApeptides. ChemBioChem, 2014, 15(16), 2420-2426.

22. Li, Y.; Smith, C.; Wu, H.; Teng, P.; Shi, Y.; Padhee, S.; Jones, T.; Nguyen, A.; Cao, C.; Yin, H. and Cai, J. Short antimicrobial lipo-α/γ-AA hybrid peptides. ChemBioChem, 2014, 15(15), 2275-2280.

21. Teng, P.; Zhang, X.; Wu, H.; Qiao, Q.; Sebti, S. M.; Cai, J. Identification of novel inhibitors that disrupt STAT3/DNA interaction from γ-AApeptide OBOC combinatorial library. Chem. Commun. 2014, 50(63), 8739-8742.

20. Wang, Y.; Costanza, F.; Wu, H.; Song, D.; Cai, J.; Li, Q. PEG-poly (amino acid)s-encapsulated Tanshinone IIA as potential therapeutics for the treatment of hepatoma. J. Mat. Chem. B. 2014, 2(20), 3115-3122.

19. Padhee, S.; Smith, C.; Wu, H.; Li, Y.; Manoj, N.; Qiao, Q.; Khan, Z.; Cao, C.; Yin, H.; Cai, J. The development of antimicrobial γ-AApeptides that suppress pro-inflammatory immune responses. ChemBioChem, 2014, 15, 688-694.

18. Li, Y.; Smith, C.; Wu, H.; Padhee, S.; Manoj, N.; Cardiello, J.; Qiao, Q.; Cao, C.; Yin, H.; Cai, J. Lipidated Cyclic γ-AApeptides Display Both Antimicrobial and Anti-inflammatory Activity. ACS Chem. Biol., 2014, 9, 211-217.

17. Costanza, F.; Padhee, S.; Wu, H.; Wang, Y.; Revenis, J.; Cao, C.; Li, Q.; Cai, J. Investigation of antimicrobial PEG-poly(amino acid)s. RSC Advances, 2014, 4, 2089-2095.

16. Wu, H.; Teng, P.; Niu, Y.; Li, Q.; Cai, J. Polymyxin derivatives: a patent evaluation (WO2012168820). Expert Opin. Ther. Pat., 2013, 23(8), 1075-81.

15. Niu, Y.; Wu, H.; Li, Y.; Hu, Y.; Padhee, S.; Li, Q.; Cao, C.; Cai, J. AApeptides as a new class of antimicrobial agents. Org. Biomol. Chem. 2013, 11, 4283-4290.

14. Li, Y.; Wu, H.; Niu, Y.; Hu, Y.; Li, Q.; Cao, C.; Cai, J. Development of RNA Aptamer-Based Therapeutic Agents. Curr. Med. Chem., 2013, 20, 3655-3663.

13. Wu, H.; Amin, M. N.; Niu, Y.; Qiao, Q.; Harfouch, N.; Nimer, A.; Cai, J. Solid Phase Synthesis of γ-AApeptides Using a Novel Submonomeric Approach. Org. Lett. 2012, 14, 3446-3449.

12. Wu, H.; Niu, Y.; Padhee, S.; Wang, R. E.; Li, Y.; Qiao, Q.; Bai, G.; Cao, C.; Cai, J. Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development. Chem. Sci., 2012, 3, 2570-2575.

11. Niu, Y.; Wu, H.; Huang, R.; Qiao, Q.; Costanza, F.; Wang, X.; Hu, Y.; Amin, M. N.; Nguyen, A.; Zhang, J.; Haller, E.; Ma, S.; Li, X.; Cai, J. Nanorods formed from a new class of peptidomimetics. Macromolecules, 2012, 45, 7350-7355.

10. Niu, Y.; Wang, R. E.; Wu, H.; Cai, J. Recent development of small antimicrobial peptidomimetics. Future Med. Chem. 2012, 4, 14, 1853-1862.

9. Niu, Y.; Padhee, S.; Wu, H.; Bai, G.; Qiao, Q.; Hu, Y.; Harrington, L.; Burda, W. L.; Shaw, L.N.; Cao, C.; Cai, J. Lipo-γ-AApeptides as a new class of potent and broad-spectrum antimicrobial agents. J. Med. Chem. 2012, 55(8), 4003-4009.

8. Niu, Y.; Bai, G.; Wu, H.; Wang, R. E.; Qiao, Q.; Padhee, S.; Buzzeo, R.; Cao, C.; Cai, C.; Cellular translocation of a γ -AApeptide mimetic of Tat peptide. Mol. Pharmaceutics. 2012, 9(5), 1529-1534.

7. Wang, R. E.; Niu, Y.; Wu, H.; Hu, Y.; Cai, J. Development of NGR-Based Anti-Cancer Agents for Targeted Therapeutics and Imaging. Anticancer Agents Med. Chem. 2012, 12(1), 76-86.

6. Wang, R. E.; Costanza, F.; Niu, Y.; Wu, H.; Hu, Y.; Hang, W.; Sun, Y.; Cai, J. Development of self-immolative dendrimers for drug delivery and sensing. J. Control. Release. 2012, 159, 154-163.

5. Wang, R. E.; Wu, H.; Niu, Y.; Cai, J. Improving the Stability of Aptamers by Chemical Modification. Curr. Med. Chem. 2011, 18, 4126-4138.

4. Niu, Y.; Padhee, S.; Wu, H.; Bai, G.; Harrington, L.; Burda, W. N.; Shaw, L. N.; Cao, C.; Cai, J. Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. Chem. Commun. 2011, 47 (44), 12197-12199.

3. Wang, R. E.; Niu, Y.; Wu, H.; Amin, M. N.; Cai, J. Development of NGR peptide-based agents for tumor imaging. Am. J. Nucl. Med. Mol. Imaging 2011, 1(1), 36-46.

2. Niu, Y.; Jones, A.; Wu, H.; Varani, G.; Cai, J. γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org. Biomol. Chem., 2011, 9 (19), 6604-6609.

1. Padhee, S.; Hu, Y.; Niu, Y.; Bai, G.; Wu, H.; Costanza, F.; West, L.; Harrington, L.; Shaw, L. N.; Cao, C.; Cai, J. Non-Hemolytic α-AApeptides as Antimicrobial Peptidomimetics. Chem. Commun. 2011, 47(34), 9729–9731.

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